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OALib Journal期刊
ISSN: 2333-9721
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ISSN Print: 1545-9985

ISSN Online:

主页: https://www.nature.com/nsmb

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A symmetric toggle switch explains the onset of random X inactivation in different mammals

Crystal structure of a mammalian Wnt–frizzled complex

Transcription preinitiation complex structure and dynamics provide insight into genetic diseases

Genome-wide identification of mRNA 5-methylcytosine in mammals

Co-translational assembly of proteasome subunits in NOT1-containing assemblysomes

Nascent-protein ubiquitination is required for heat shock–induced gene downregulation in human cells

Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly

Structures of the ISWI–nucleosome complex reveal a conserved mechanism of chromatin remodeling

Dynamic reorganization of the genome shapes the recombination landscape in meiotic prophase

Apn2 resolves blocked 3′ ends and suppresses Top1-induced mutagenesis at genomic rNMP sites

Dynamics and selective remodeling of the DNA-binding domains of RPA

Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine

Attenuated chromatin compartmentalization in meiosis and its maturation in sperm development

Structure of the 80S ribosome–Xrn1 nuclease complex

RNA structure maps across mammalian cellular compartments

Evolution from covalent conjugation to non-covalent interaction in the ubiquitin-like ATG12 system

Three-dimensional genome structures of single sensory neurons in mouse visual and olfactory systems

Broad-spectrum enzymatic inhibition of CRISPR-Cas12a

Receptor subtype discrimination using extensive shape complementary designed interfaces

Atg2 mediates direct lipid transfer between membranes for autophagosome formation

A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos

An anti-CRISPR protein disables type V Cas12a by acetylation

PICH and TOP3A cooperate to induce positive DNA supercoiling

The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases

RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2

DNA stretching induces Cas9 off-target activity

Structural basis of broad ebolavirus neutralization by a human survivor antibody

The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening

A folded conformation of MukBEF and cohesin

KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells

Mechanism for recycling tRNAs on stalled ribosomes

Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1

A tethered-inchworm model of SMC DNA translocation

Cryo-EM structure of the yeast respiratory supercomplex

Understanding molecular mechanisms in cell signaling through natural and artificial sequence variation

Ribosome–NatA architecture reveals that rRNA expansion segments coordinate N-terminal acetylation

RNA motifs and combinatorial prediction of interactions, stability and localization of noncoding RNAs

Organellar TRP channels

A novel class of microRNA-recognition elements that function only within open reading frames

A molecular mechanism for calcium-mediated synaptotagmin-triggered exocytosis

Structure of a functional obligate complex III2IV2 respiratory supercomplex from Mycobacterium smegmatis

Direct observation of topoisomerase IA gate dynamics

Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration

DNA G-quadruplex structures mold the DNA methylome

De novo design of a non-local β-sheet protein with high stability and accuracy

DNA damage-induced cell death relies on SLFN11-dependent cleavage of distinct type II tRNAs

SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation

Cross-linking mass spectrometry: methods and applications in structural, molecular and systems biology

A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase

High-resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist

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