IgA—about the unexpected

Foxp3+ T reg cells control psoriasiform inflammation by restraining an IFN-I–driven CD8+ T cell response

Eosinophils can more than kill

Inhibition of UGT8 suppresses basal-like breast cancer progression by attenuating sulfatide–αVβ5 axis

Trim33 mediates the proinflammatory function of Th17 cells

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

Immune system: The “seventh sense”

Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells

Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1

Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression

Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors

Sensing danger through a “finger”

Deciphering cancer fibroblasts

Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality

Chan Soon,Chan Soon Park,Cho,David T.,David T. Shima,Dong Sun,Dong Sun Oh,Eunhyeong,Eunhyeong Lee,Gou Young,Gou Young Koh,Heung Kyu,Heung Kyu Lee,Hong,Hyung-Seok,Hyung-Seok Kim,Il-Kug,Il-Kug Kim,Injune,Injune Kim,Jee Myung,Jee Myung Yang,Jeong Hoon,Jeong Hoon Kim,Jong Bae,Jong Bae Park,Ju-Hee,Ju-Hee Kim,Kangsan,Kangsan Kim,Kim,Koh,Lee,Oh,Park,Seok Ho,Seok Ho Hong,Seongyeol,Seongyeol Park,Seungjoo,Seungjoo Lee,Shima,Yang,Young Hoon,Young Hoon Kim,Young Hyun,Young Hyun Cho,Young Seok,Young Seok Ju

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

HPV: CIB1 is for EVER and EVER

Contextual control of skin immunity and inflammation by Corynebacterium

Allyson L.,Allyson L. Byrd,Belkaid,Bouladoux,Byrd,Chen,Claesen,Constantinides,Eric D.,Eric D. Merrill,Fischbach,Jan,Jan Claesen,Merrill,Michael A.,Michael A. Fischbach,Michael G.,Michael G. Constantinides,Nicolas,Nicolas Bouladoux,Ridaura,Samira,Samira Tamoutounour,Tamoutounour,Vanessa K.,Vanessa K. Ridaura,Y. Erin,Y. Erin Chen,Yasmine,Yasmine Belkaid

Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches

Abarrategi,Ander,Ander Abarrategi,Diana,Diana Passaro,Dominique Bonnet,Grey,Kevin,Kevin Rouault-Pierre,Mian,Passaro,Rouault-Pierre,Syed A.,Syed A. Mian,William,William Grey

BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions

Brati,Brati Das,Das,Hailong,Hailong Hou,He,Hou,Hu,Riqiang,Riqiang Yan,Wanxia,Wanxia He,Xiangyou,Xiangyou Hu,Yan

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

Alpha S.,Alpha S. Yap,Bezbradica,Bierschenk,Boucher,Caroline L.,Caroline L. Holley,Chen,Coll,Connie M.,Connie M. Ross,Damien,Damien Bierschenk,Dave,Dave Boucher,Gomez,Guillermo A.,Guillermo A. Gomez,Holley,Jelena S.,Jelena S. Bezbradica,Jessica L.,Jessica L. Teo,Kaiwen W.,Kaiwen W. Chen,Kate,Kate Schroder,Katryn J.,Katryn J. Stacey,Mercedes,Mercedes Monteleone,Monteleone,Rebecca C.,Rebecca C. Coll,Ross,Schroder,Stacey,Teo,Yap

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease

ARID5B regulates metabolic programming in human adaptive NK cells

Refusing to TAP out: 16 new human TEIPPs identified

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation

Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny

IL-7–dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes

ApoE facilitates the microglial response to amyloid plaque pathology

Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy

Regulation of amyloid-β dynamics and pathology by the circadian clock

Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal

Death, eaters, and dark marks

Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain

Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies

CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss

ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates

Interleukin-10 stiffens the heart

Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning

TAK1ng control: TAK1 restrains NLRP3 activation

Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation

SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-β signaling

Germline deletion of CIN85 in humans with X chromosome–linked antibody deficiency

Repressing the repressor: Ezh2 mediates macrophage activation

Selective inhibition of the p38α MAPK–MK2 axis inhibits inflammatory cues including inflammasome priming signals

Sox12 promotes T reg differentiation in the periphery during colitis

A20-binding inhibitor of NF-κB (ABIN) 2 negatively regulates allergic airway inflammation

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

Primary atopic disorders

CD49b defines functionally mature Treg cells that survey skin and vascular tissues